Drug interactions
Memantine-donepezil + Vandetanib
Severity: Major
Memantine-donepezil and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2, which contributes to renal secretion of memantine, so memantine levels may rise. Vandetanib and donepezil can each prolong the QT interval, so the combination also adds cardiac risk.
What this interaction means in plain words
Memantine-donepezil and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Memantine-donepezil belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
OCT2 inhibition reduces renal clearance of memantine, and vandetanib and donepezil have additive QT-prolonging effects.
What to do
Monitor ECG and electrolytes, and watch for memantine adverse effects such as dizziness and confusion. Consider an alternative to donepezil in patients with QT risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Vandetanib?
MediHelp rates the interaction as major. Memantine-donepezil and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib inhibits OCT2, which contributes to renal secretion of memantine, so memantine levels may rise. Vandetanib and donepezil can each prolong the QT interval, so the combination also adds cardiac risk.
How serious is the interaction between Memantine-donepezil and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for memantine adverse effects such as dizziness and confusion. Consider an alternative to donepezil in patients with QT risk.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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