Drug interactions
Meningococcal a c y and w-135 diphtheria conjugate vaccine + Oxaliplatin
Severity: Moderate
Meningococcal a c y and w-135 diphtheria conjugate vaccine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin may reduce the immunogenicity of meningococcal conjugate vaccine. The resulting antibody titers may be lower and less durable.
What this interaction means in plain words
Meningococcal a c y and w-135 diphtheria conjugate vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Give the vaccine at least 2 weeks before chemotherapy if possible; if given during therapy, plan revaccination about 3 months after treatment ends once immunity has recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Meningococcal a c y and w-135 diphtheria conjugate vaccine with Oxaliplatin?
MediHelp rates the interaction as moderate. Meningococcal a c y and w-135 diphtheria conjugate vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin may reduce the immunogenicity of meningococcal conjugate vaccine. The resulting antibody titers may be lower and less durable.
How serious is the interaction between Meningococcal a c y and w-135 diphtheria conjugate vaccine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before chemotherapy if possible; if given during therapy, plan revaccination about 3 months after treatment ends once immunity has recovered.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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