Drug interactions
Meningococcal a c y and w-135 polysaccharide vaccine combined + Tacrolimus
Severity: Moderate
Meningococcal a c y and w-135 polysaccharide vaccine combined and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may reduce the antibody response to meningococcal vaccine. The vaccine is non-live, so there is no infection risk and vaccination is still recommended in at-risk patients.
What this interaction means in plain words
Meningococcal a c y and w-135 polysaccharide vaccine combined and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell dependent antibody production after vaccination.
What to do
Vaccinate as indicated, preferring a conjugate vaccine, and do not stop tacrolimus. Consider checking antibody response and boosting per local schedules.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Meningococcal a c y and w-135 polysaccharide vaccine combined with Tacrolimus?
MediHelp rates the interaction as moderate. Meningococcal a c y and w-135 polysaccharide vaccine combined and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may reduce the antibody response to meningococcal vaccine. The vaccine is non-live, so there is no infection risk and vaccination is still recommended in at-risk patients.
How serious is the interaction between Meningococcal a c y and w-135 polysaccharide vaccine combined and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated, preferring a conjugate vaccine, and do not stop tacrolimus. Consider checking antibody response and boosting per local schedules.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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