Drug interactions
Meningococcal group b vaccine + Mycophenolate mofetil
Severity: Moderate
Meningococcal group b vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may reduce antibody responses to the non-live meningococcal B vaccine. Immunosuppressed patients remain at risk of invasive disease, so reduced protection matters. The vaccine itself is safe to give.
What this interaction means in plain words
Meningococcal group b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: suppressed lymphocyte proliferation reduces vaccine antibody response.
What to do
Vaccinate according to schedule, ideally before starting immunosuppression when feasible. Follow the immunocompromised dosing schedule and consider checking the response where indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Meningococcal group b vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate may reduce antibody responses to the non-live meningococcal B vaccine. Immunosuppressed patients remain at risk of invasive disease, so reduced protection matters. The vaccine itself is safe to give.
How serious is the interaction between Meningococcal group b vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to schedule, ideally before starting immunosuppression when feasible. Follow the immunocompromised dosing schedule and consider checking the response where indicated.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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