Drug interactions
Meningococcal group b vaccine + Sirolimus
Severity: Moderate
Meningococcal group b vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from sirolimus may blunt the antibody response to the meningococcal B vaccine, leaving the patient with less protection than expected. The vaccine is non-live, so the concern is reduced efficacy rather than infection from the vaccine.
What this interaction means in plain words
Meningococcal group b vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism, as mTOR inhibition dampens lymphocyte proliferation and vaccine-induced immune responses.
What to do
Where possible, complete vaccination before starting sirolimus. Otherwise vaccinate anyway and consider checking antibody response or giving additional doses according to local guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meningococcal group b vaccine and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Meningococcal group b vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from sirolimus may blunt the antibody response to the meningococcal B vaccine, leaving the patient with less protection than expected. The vaccine is non-live, so the concern is reduced efficacy rather than infection from the vaccine.
How serious is the interaction between Meningococcal group b vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, complete vaccination before starting sirolimus. Otherwise vaccinate anyway and consider checking antibody response or giving additional doses according to local guidance.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
