Drug interactions
Meningococcal group b vaccine + Tacrolimus
Severity: Moderate
Meningococcal group b vaccine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from tacrolimus can blunt the antibody response to inactivated vaccines such as meningococcal group B vaccine. Protection may therefore be weaker or shorter-lived in transplant recipients.
What this interaction means in plain words
Meningococcal group b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell activation and thereby reduces the vaccine-induced immune response.
What to do
Vaccinate ideally before transplantation or when immunosuppression is at its lowest, and do not withhold the vaccine in at-risk patients. Consider checking antibody response where available and follow local schedules for booster doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Meningococcal group b vaccine with Tacrolimus?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from tacrolimus can blunt the antibody response to inactivated vaccines such as meningococcal group B vaccine. Protection may therefore be weaker or shorter-lived in transplant recipients.
How serious is the interaction between Meningococcal group b vaccine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before transplantation or when immunosuppression is at its lowest, and do not withhold the vaccine in at-risk patients. Consider checking antibody response where available and follow local schedules for booster doses.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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