Drug interactions
Meperidine + Metoclopramide intranasal
Severity: Moderate
Meperidine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids antagonize the gastric prokinetic effect of metoclopramide, and both can add to CNS effects such as drowsiness. The result can be reduced antiemetic and prokinetic benefit and greater sedation.
What this interaction means in plain words
Meperidine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated reduction of gastrointestinal motility opposes metoclopramide's prokinetic action, with additive CNS depression.
What to do
Monitor for loss of metoclopramide effect and excess sedation; consider an alternative antiemetic if gastrointestinal response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Meperidine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids antagonize the gastric prokinetic effect of metoclopramide, and both can add to CNS effects such as drowsiness. The result can be reduced antiemetic and prokinetic benefit and greater sedation.
How serious is the interaction between Meperidine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of metoclopramide effect and excess sedation; consider an alternative antiemetic if gastrointestinal response is inadequate.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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