Drug interactions
Meperidine + Molindone
Severity: Moderate
Meperidine and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Molindone may add to opioid sedation and hypotension, and meperidine's serotonergic action combined with dopamine blockade creates a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Meperidine and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible serotonergic and dopaminergic effects.
What to do
Monitor for sedation, hypotension, hyperthermia, rigidity and altered mental status. Use lower starting doses and adjust to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Molindone?
MediHelp rates the interaction as moderate. Meperidine and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Molindone may add to opioid sedation and hypotension, and meperidine's serotonergic action combined with dopamine blockade creates a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Meperidine and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension, hyperthermia, rigidity and altered mental status. Use lower starting doses and adjust to response.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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