Drug interactions
Meperidine + Phenylephrine po
Severity: Minor
Meperidine and Phenylephrine po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is a weak sympathomimetic with modest central effects, and any offset of opioid sedation is unreliable. The combination may modestly increase blood pressure or heart rate, and clinically important interaction is not expected in most patients.
What this interaction means in plain words
Meperidine and Phenylephrine po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects; the interaction is theoretical and the mechanism is not well established.
What to do
No routine change is needed. Monitor blood pressure in patients with cardiovascular disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Phenylephrine po?
MediHelp rates the interaction as minor. Meperidine and Phenylephrine po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral phenylephrine is a weak sympathomimetic with modest central effects, and any offset of opioid sedation is unreliable. The combination may modestly increase blood pressure or heart rate, and clinically important interaction is not expected in most patients.
How serious is the interaction between Meperidine and Phenylephrine po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood pressure in patients with cardiovascular disease.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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