Drug interactions
Meperidine + Pimozide
Severity: Moderate
Meperidine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide and meperidine have additive sedative and hypotensive effects. Rare serotonin syndrome or neuroleptic malignant syndrome is also possible, and pimozide prolongs the QT interval, which is a concern in a sedated, medically complex patient.
What this interaction means in plain words
Meperidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible serotonergic and dopamine-blocking effects.
What to do
Use low doses, monitor sedation, blood pressure and signs of serotonin toxicity, and check ECG and electrolytes if other QT risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Meperidine with Pimozide?
MediHelp rates the interaction as moderate. Meperidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide and meperidine have additive sedative and hypotensive effects. Rare serotonin syndrome or neuroleptic malignant syndrome is also possible, and pimozide prolongs the QT interval, which is a concern in a sedated, medically complex patient.
How serious is the interaction between Meperidine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low doses, monitor sedation, blood pressure and signs of serotonin toxicity, and check ECG and electrolytes if other QT risks are present.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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