Drug interactions
Meperidine + Sage
Severity: Minor
Meperidine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage is a herbal product with reported mild sedative properties, so it could add to the CNS depression caused by meperidine. The clinical significance is uncertain and based on theory.
What this interaction means in plain words
Meperidine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects; the mechanism for sage is not firmly established.
What to do
Advise the patient to report excessive drowsiness and avoid concentrated sage supplements. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Sage?
MediHelp rates the interaction as minor. Meperidine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage is a herbal product with reported mild sedative properties, so it could add to the CNS depression caused by meperidine. The clinical significance is uncertain and based on theory.
How serious is the interaction between Meperidine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report excessive drowsiness and avoid concentrated sage supplements. No routine dose change is needed.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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