Drug interactions
Meperidine + Same
Severity: Moderate
Meperidine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) may increase serotonergic activity, and meperidine inhibits serotonin reuptake. The combination could raise the risk of serotonin syndrome.
What this interaction means in plain words
Meperidine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; SAMe's serotonergic action is not well characterised.
What to do
Avoid combining where feasible and prefer a non-serotonergic opioid. If used together, monitor for features of serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Same?
MediHelp rates the interaction as moderate. Meperidine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) may increase serotonergic activity, and meperidine inhibits serotonin reuptake. The combination could raise the risk of serotonin syndrome.
How serious is the interaction between Meperidine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where feasible and prefer a non-serotonergic opioid. If used together, monitor for features of serotonin syndrome.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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