Drug interactions
Meperidine + Sumatriptan intranasal
Severity: Moderate
Meperidine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonergic systems, and serotonin syndrome has been reported with triptans combined with serotonergic agents. The actual risk with triptans is thought to be low but cannot be excluded.
What this interaction means in plain words
Meperidine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects through 5-HT1B/1D agonism and meperidine serotonin reuptake inhibition.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and autonomic instability, especially after dose changes. Consider a non-serotonergic opioid if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Meperidine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on serotonergic systems, and serotonin syndrome has been reported with triptans combined with serotonergic agents. The actual risk with triptans is thought to be low but cannot be excluded.
How serious is the interaction between Meperidine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and autonomic instability, especially after dose changes. Consider a non-serotonergic opioid if available.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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