Drug interactions
Meperidine + Triprolidine
Severity: Major
Meperidine and Triprolidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with the opioid meperidine increases sedation, psychomotor impairment and the risk of respiratory depression. Meperidine's anticholinergic properties and active metabolite may further contribute to confusion, particularly in older adults.
What this interaction means in plain words
Meperidine and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meperidine belongs to Musculoskeletal; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination where possible, or use the lowest effective doses with monitoring of sedation and respiratory rate. Advise the patient against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triprolidine
Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Triprolidine?
MediHelp rates the interaction as major. Meperidine and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedating antihistamine with the opioid meperidine increases sedation, psychomotor impairment and the risk of respiratory depression. Meperidine's anticholinergic properties and active metabolite may further contribute to confusion, particularly in older adults.
How serious is the interaction between Meperidine and Triprolidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective doses with monitoring of sedation and respiratory rate. Advise the patient against alcohol and driving.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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