Drug interactions
Meperidine + Yohimbine
Severity: Minor
Meperidine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant effects that may partly offset opioid sedation without protecting against respiratory depression. It can also raise blood pressure and heart rate, and evidence for a significant interaction is limited.
What this interaction means in plain words
Meperidine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing central effects through alpha-2 adrenergic antagonism; the mechanism is not well established.
What to do
Monitor blood pressure and heart rate. Do not assume sedation or respiratory depression is prevented.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Yohimbine?
MediHelp rates the interaction as minor. Meperidine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant effects that may partly offset opioid sedation without protecting against respiratory depression. It can also raise blood pressure and heart rate, and evidence for a significant interaction is limited.
How serious is the interaction between Meperidine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate. Do not assume sedation or respiratory depression is prevented.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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