Drug interactions
Meperidine + Zotepine
Severity: Moderate
Meperidine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating antipsychotic that adds to meperidine's CNS depression, with increased drowsiness and hypotension. Zotepine also lowers the seizure threshold, which may be relevant given the risk of seizures from normeperidine.
What this interaction means in plain words
Meperidine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive lowering of seizure threshold.
What to do
Use reduced doses and monitor sedation, blood pressure and seizure activity. Consider an alternative opioid in patients with seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Zotepine?
MediHelp rates the interaction as moderate. Meperidine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating antipsychotic that adds to meperidine's CNS depression, with increased drowsiness and hypotension. Zotepine also lowers the seizure threshold, which may be relevant given the risk of seizures from normeperidine.
How serious is the interaction between Meperidine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor sedation, blood pressure and seizure activity. Consider an alternative opioid in patients with seizure risk.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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