Drug interactions
Mestranol + Midazolam
Severity: Minor
Mestranol and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens such as mestranol may weakly inhibit CYP3A4 and slightly reduce midazolam clearance, with a possible modest prolongation of sedation. The effect is expected to be small.
What this interaction means in plain words
Mestranol and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by mestranol reducing midazolam metabolism.
What to do
Be aware of possible prolonged sedation and adjust the midazolam dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Mestranol with Midazolam?
MediHelp rates the interaction as minor. Mestranol and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens such as mestranol may weakly inhibit CYP3A4 and slightly reduce midazolam clearance, with a possible modest prolongation of sedation. The effect is expected to be small.
How serious is the interaction between Mestranol and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible prolonged sedation and adjust the midazolam dose to response.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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