Drug interactions
Mestranol + Moxifloxacin
Severity: Minor
Mestranol and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Broad-spectrum antibiotics have been suspected of reducing estrogen contraceptive efficacy, but controlled data show no consistent effect for non-rifamycin antibiotics. The clinical risk is low.
What this interaction means in plain words
Mestranol and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical disruption of gut flora involved in estrogen enterohepatic recirculation; not well established.
What to do
No routine change needed. Advise additional contraception if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Mestranol with Moxifloxacin?
MediHelp rates the interaction as minor. Mestranol and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Broad-spectrum antibiotics have been suspected of reducing estrogen contraceptive efficacy, but controlled data show no consistent effect for non-rifamycin antibiotics. The clinical risk is low.
How serious is the interaction between Mestranol and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Advise additional contraception if vomiting or severe diarrhea occurs.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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