Drug interactions
Mestranol + Tacrolimus
Severity: Minor
Mestranol and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may modestly raise exposure to estrogens such as mestranol. Estrogen-related adverse effects could become more likely, and estrogens have also been reported to raise tacrolimus levels.
What this interaction means in plain words
Mestranol and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by tacrolimus, with additional weak CYP3A4 effects, alters estrogen exposure; the evidence is limited.
What to do
No routine dose change is needed; watch for estrogenic adverse effects and monitor tacrolimus trough levels if hormonal therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Mestranol with Tacrolimus?
MediHelp rates the interaction as minor. Mestranol and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may modestly raise exposure to estrogens such as mestranol. Estrogen-related adverse effects could become more likely, and estrogens have also been reported to raise tacrolimus levels.
How serious is the interaction between Mestranol and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for estrogenic adverse effects and monitor tacrolimus trough levels if hormonal therapy is started or stopped.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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