Drug interactions
Mestranol + Tizanidine
Severity: Moderate
Mestranol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol is converted to ethinylestradiol, and oral contraceptives are known to reduce tizanidine clearance. Tizanidine levels may rise, increasing sedation, dizziness and hypotension.
What this interaction means in plain words
Mestranol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen-mediated inhibition of CYP1A2 reduces tizanidine metabolism.
What to do
Monitor for sedation and hypotension and start tizanidine at a low dose. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Mestranol with Tizanidine?
MediHelp rates the interaction as moderate. Mestranol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mestranol is converted to ethinylestradiol, and oral contraceptives are known to reduce tizanidine clearance. Tizanidine levels may rise, increasing sedation, dizziness and hypotension.
How serious is the interaction between Mestranol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and hypotension and start tizanidine at a low dose. Reduce the dose if adverse effects occur.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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