Drug interactions
Mestranol + Voriconazole
Severity: Moderate
Mestranol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can raise estrogen exposure, and mestranol is converted to ethinylestradiol, which is metabolized by CYP3A4. Higher estrogen levels may cause nausea, breast tenderness, fluid retention and increased thrombotic risk.
What this interaction means in plain words
Mestranol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 and reduces clearance of mestranol and its active metabolite ethinylestradiol.
What to do
Monitor for estrogen excess effects such as nausea, hypertension and edema. Consider a lower estrogen dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Mestranol with Voriconazole?
MediHelp rates the interaction as moderate. Mestranol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can raise estrogen exposure, and mestranol is converted to ethinylestradiol, which is metabolized by CYP3A4. Higher estrogen levels may cause nausea, breast tenderness, fluid retention and increased thrombotic risk.
How serious is the interaction between Mestranol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess effects such as nausea, hypertension and edema. Consider a lower estrogen dose if symptoms occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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