Drug interactions
Metaproterenol + Metoprolol
Severity: Moderate
Metaproterenol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol antagonizes the bronchodilator action of metaproterenol, and its beta-1 selectivity is lost at higher doses. This can cause bronchospasm and a poor response to the beta-agonist in patients with asthma or COPD.
What this interaction means in plain words
Metaproterenol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive beta-adrenergic receptor antagonism opposing beta-agonist effects.
What to do
Use the lowest effective dose of metoprolol and monitor respiratory status. Consider an alternative to the beta-blocker in patients with significant reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metaproterenol with Metoprolol?
MediHelp rates the interaction as moderate. Metaproterenol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol antagonizes the bronchodilator action of metaproterenol, and its beta-1 selectivity is lost at higher doses. This can cause bronchospasm and a poor response to the beta-agonist in patients with asthma or COPD.
How serious is the interaction between Metaproterenol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of metoprolol and monitor respiratory status. Consider an alternative to the beta-blocker in patients with significant reactive airway disease.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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