Drug interactions
Metaproterenol + Perphenazine
Severity: Minor
Metaproterenol and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No reliable sedation interaction exists between these drugs. Perphenazine can prolong QT and metaproterenol may cause tachycardia and hypokalemia, so a small theoretical additive arrhythmia risk exists at higher doses.
What this interaction means in plain words
Metaproterenol and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive cardiac effects; no established mechanism for a sedation interaction.
What to do
No routine change is needed. Consider checking potassium and an ECG in patients with cardiac disease or taking high doses of metaproterenol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Metaproterenol with Perphenazine?
MediHelp rates the interaction as minor. Metaproterenol and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No reliable sedation interaction exists between these drugs. Perphenazine can prolong QT and metaproterenol may cause tachycardia and hypokalemia, so a small theoretical additive arrhythmia risk exists at higher doses.
How serious is the interaction between Metaproterenol and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Consider checking potassium and an ECG in patients with cardiac disease or taking high doses of metaproterenol.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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