Drug interactions
Metaxalone + Methadone
Severity: Moderate
Metaxalone and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a sedating muscle relaxant, and combined use with methadone increases drowsiness and respiratory depression. Impaired alertness and falls are the main practical concerns.
What this interaction means in plain words
Metaxalone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor for sedation and slowed breathing. Counsel the patient to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Methadone?
MediHelp rates the interaction as moderate. Metaxalone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a sedating muscle relaxant, and combined use with methadone increases drowsiness and respiratory depression. Impaired alertness and falls are the main practical concerns.
How serious is the interaction between Metaxalone and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and slowed breathing. Counsel the patient to avoid driving and alcohol.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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