Drug interactions
Metformin + Norethisterone
Severity: Minor
Metformin and Norethisterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins may slightly worsen glucose tolerance and thereby oppose the glucose-lowering effect of metformin. Norethisterone has only a small effect, and it is rarely clinically important.
What this interaction means in plain words
Metformin and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Norethisterone belongs to Endocrine.
Why it happens
Progestogenic reduction in insulin sensitivity may oppose the antihyperglycemic effect of metformin.
What to do
Monitor blood glucose when starting or stopping norethisterone and adjust diabetes therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Norethisterone?
MediHelp rates the interaction as minor. Metformin and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins may slightly worsen glucose tolerance and thereby oppose the glucose-lowering effect of metformin. Norethisterone has only a small effect, and it is rarely clinically important.
How serious is the interaction between Metformin and Norethisterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping norethisterone and adjust diabetes therapy if needed.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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