Drug interactions
Metformin + Tipranavir
Severity: Moderate
Metformin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, like other protease inhibitors, can cause insulin resistance and hyperglycemia that may counter the effect of metformin. Diabetes control may need reassessment.
What this interaction means in plain words
Metformin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair insulin signaling and glucose uptake, opposing metformin's effect.
What to do
Monitor glucose and HbA1c after starting tipranavir and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Metformin with Tipranavir?
MediHelp rates the interaction as moderate. Metformin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, like other protease inhibitors, can cause insulin resistance and hyperglycemia that may counter the effect of metformin. Diabetes control may need reassessment.
How serious is the interaction between Metformin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting tipranavir and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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