Drug interactions
Metformin-pioglitazone + Mifepristone
Severity: Moderate
Metformin-pioglitazone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can raise pioglitazone concentrations, increasing glucose-lowering effect and dose-related adverse effects such as edema. The effect is most relevant with long-term high-dose mifepristone used for Cushing syndrome.
What this interaction means in plain words
Metformin-pioglitazone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP2C8, the main enzyme metabolizing pioglitazone.
What to do
Use the lowest effective pioglitazone dose and monitor blood glucose and for edema during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Mifepristone?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone can raise pioglitazone concentrations, increasing glucose-lowering effect and dose-related adverse effects such as edema. The effect is most relevant with long-term high-dose mifepristone used for Cushing syndrome.
How serious is the interaction between Metformin-pioglitazone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pioglitazone dose and monitor blood glucose and for edema during co-therapy.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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