Drug interactions
Metformin-pioglitazone + Paclitaxel
Severity: Minor
Metformin-pioglitazone and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized partly by CYP2C8, and pioglitazone is a weak CYP2C8 inhibitor. Exposure to paclitaxel could rise slightly, but significant clinical effects have not been well established.
What this interaction means in plain words
Metformin-pioglitazone and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Paclitaxel belongs to Oncology.
Why it happens
Weak inhibition of CYP2C8 by pioglitazone may reduce paclitaxel metabolism.
What to do
No routine change needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-pioglitazone and Paclitaxel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-pioglitazone
Other interactions of Paclitaxel
Frequently asked questions
Can I take Metformin-pioglitazone with Paclitaxel?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is metabolized partly by CYP2C8, and pioglitazone is a weak CYP2C8 inhibitor. Exposure to paclitaxel could rise slightly, but significant clinical effects have not been well established.
How serious is the interaction between Metformin-pioglitazone and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
