Drug interactions
Metformin-pioglitazone + Tafenoquine
Severity: Moderate
Metformin-pioglitazone and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits OCT2 and MATE transporters in vitro, which may reduce renal elimination of metformin and raise its levels. This increases the risk of metformin adverse effects including lactic acidosis.
What this interaction means in plain words
Metformin-pioglitazone and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE-mediated renal secretion of metformin.
What to do
Monitor glucose and renal function and consider reducing the metformin dose if coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Metformin-pioglitazone with Tafenoquine?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits OCT2 and MATE transporters in vitro, which may reduce renal elimination of metformin and raise its levels. This increases the risk of metformin adverse effects including lactic acidosis.
How serious is the interaction between Metformin-pioglitazone and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function and consider reducing the metformin dose if coadministration is needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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