Drug interactions
Metformin-pioglitazone + Tranylcypromine
Severity: Moderate
Metformin-pioglitazone and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as tranylcypromine can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The risk is modest with metformin and pioglitazone alone but may be additive.
What this interaction means in plain words
Metformin-pioglitazone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
Non-selective MAO inhibition may enhance insulin sensitivity and hypoglycemic effects.
What to do
Monitor blood glucose when starting, changing or stopping tranylcypromine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Tranylcypromine?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as tranylcypromine can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The risk is modest with metformin and pioglitazone alone but may be additive.
How serious is the interaction between Metformin-pioglitazone and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping tranylcypromine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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