Drug interactions
Metformin-repaglinide + Nizatidine
Severity: Minor
Metformin-repaglinide and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine is eliminated by renal tubular cationic secretion and may compete with metformin for this pathway, modestly raising metformin exposure. The effect is generally small, though it may matter in patients with reduced renal function.
What this interaction means in plain words
Metformin-repaglinide and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) reduces metformin clearance.
What to do
No routine change is needed. Monitor glycemic control and renal function, and reduce the metformin dose if exposure-related adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Metformin-repaglinide with Nizatidine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nizatidine is eliminated by renal tubular cationic secretion and may compete with metformin for this pathway, modestly raising metformin exposure. The effect is generally small, though it may matter in patients with reduced renal function.
How serious is the interaction between Metformin-repaglinide and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor glycemic control and renal function, and reduce the metformin dose if exposure-related adverse effects appear.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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