Drug interactions
Metformin-repaglinide + Prednisone
Severity: Moderate
Metformin-repaglinide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone raises blood glucose through its glucocorticoid effects and can reduce the effectiveness of metformin and repaglinide. Hyperglycemia may be marked with higher doses or longer courses.
What this interaction means in plain words
Metformin-repaglinide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and insulin resistance, opposing antidiabetic drugs.
What to do
Monitor blood glucose during corticosteroid therapy and increase antidiabetic therapy as needed; reduce doses again when the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Metformin-repaglinide with Prednisone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone raises blood glucose through its glucocorticoid effects and can reduce the effectiveness of metformin and repaglinide. Hyperglycemia may be marked with higher doses or longer courses.
How serious is the interaction between Metformin-repaglinide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and increase antidiabetic therapy as needed; reduce doses again when the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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