Drug interactions
Metformin-repaglinide + Quetiapine
Severity: Moderate
Metformin-repaglinide and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may undermine control with metformin and repaglinide. Cases of marked hyperglycemia have been reported.
What this interaction means in plain words
Metformin-repaglinide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Quetiapine induces insulin resistance and impairs beta-cell function, opposing antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c at baseline and periodically during quetiapine therapy and intensify antidiabetic treatment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Metformin-repaglinide with Quetiapine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can cause weight gain, insulin resistance and hyperglycemia, which may undermine control with metformin and repaglinide. Cases of marked hyperglycemia have been reported.
How serious is the interaction between Metformin-repaglinide and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically during quetiapine therapy and intensify antidiabetic treatment if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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