Drug interactions
Metformin-repaglinide + Quinidine
Severity: Moderate
Metformin-repaglinide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a cationic drug that competes with metformin for tubular secretion in the kidney. This can raise metformin concentrations and enhance its glucose-lowering effect and risk of adverse effects such as lactic acidosis, particularly with renal impairment.
What this interaction means in plain words
Metformin-repaglinide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular secretion via OCT2 and MATE transporters reduces metformin clearance.
What to do
Monitor blood glucose and renal function when quinidine is started or stopped. Reduce the metformin dose if gastrointestinal effects or signs of excess exposure appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Quinidine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a cationic drug that competes with metformin for tubular secretion in the kidney. This can raise metformin concentrations and enhance its glucose-lowering effect and risk of adverse effects such as lactic acidosis, particularly with renal impairment.
How serious is the interaction between Metformin-repaglinide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when quinidine is started or stopped. Reduce the metformin dose if gastrointestinal effects or signs of excess exposure appear.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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