Drug interactions
Metformin-repaglinide + Rifapentine
Severity: Moderate
Metformin-repaglinide and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an enzyme inducer that can lower repaglinide concentrations, potentially causing loss of glycemic control. The induction effect may continue for some time after rifapentine is stopped.
What this interaction means in plain words
Metformin-repaglinide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and CYP2C8 increases repaglinide metabolism.
What to do
Monitor glucose frequently and titrate repaglinide upward as needed. Reduce the dose again after rifapentine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Rifapentine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an enzyme inducer that can lower repaglinide concentrations, potentially causing loss of glycemic control. The induction effect may continue for some time after rifapentine is stopped.
How serious is the interaction between Metformin-repaglinide and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and titrate repaglinide upward as needed. Reduce the dose again after rifapentine is discontinued.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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