Drug interactions
Metformin-repaglinide + Ritonavir
Severity: Moderate
Metformin-repaglinide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and can raise repaglinide exposure, increasing hypoglycemia risk. Protease inhibitors may also cause insulin resistance and hyperglycemia, so glucose control can be unpredictable.
What this interaction means in plain words
Metformin-repaglinide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition raises repaglinide levels, while protease-inhibitor-related insulin resistance opposes glucose lowering.
What to do
Monitor blood glucose closely when ritonavir is started or stopped and adjust repaglinide dosing accordingly. Consider an alternative antidiabetic if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Ritonavir?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 and can raise repaglinide exposure, increasing hypoglycemia risk. Protease inhibitors may also cause insulin resistance and hyperglycemia, so glucose control can be unpredictable.
How serious is the interaction between Metformin-repaglinide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when ritonavir is started or stopped and adjust repaglinide dosing accordingly. Consider an alternative antidiabetic if control is unstable.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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