Drug interactions
Metformin-repaglinide + Secobarbital
Severity: Moderate
Metformin-repaglinide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is a barbiturate that induces hepatic enzymes and may lower repaglinide concentrations, reducing glycemic control. The effect may develop over days and reverse after the barbiturate is stopped.
What this interaction means in plain words
Metformin-repaglinide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 (and possibly CYP2C8) increases repaglinide metabolism.
What to do
Monitor blood glucose when starting or stopping secobarbital and adjust repaglinide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Secobarbital?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is a barbiturate that induces hepatic enzymes and may lower repaglinide concentrations, reducing glycemic control. The effect may develop over days and reverse after the barbiturate is stopped.
How serious is the interaction between Metformin-repaglinide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping secobarbital and adjust repaglinide dose accordingly.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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