Drug interactions
Metformin-repaglinide + Sertraline
Severity: Minor
Metformin-repaglinide and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as sertraline may enhance glucose lowering and occasionally cause hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually modest.
What this interaction means in plain words
Metformin-repaglinide and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Additive glucose-lowering through improved insulin sensitivity; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping sertraline, with repaglinide dose reduction if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Sertraline?
MediHelp rates the interaction as minor. Metformin-repaglinide and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as sertraline may enhance glucose lowering and occasionally cause hypoglycemia in patients on antidiabetic drugs. The effect is variable and usually modest.
How serious is the interaction between Metformin-repaglinide and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping sertraline, with repaglinide dose reduction if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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