Drug interactions
Metformin-repaglinide + Simvastatin
Severity: Minor
Metformin-repaglinide and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide may inhibit OATP1B1 and modestly increase simvastatin acid exposure, theoretically raising myopathy risk. Clinical evidence of a meaningful effect is limited.
What this interaction means in plain words
Metformin-repaglinide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Simvastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of simvastatin acid.
What to do
No routine adjustment is needed; advise the patient to report muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Simvastatin?
MediHelp rates the interaction as minor. Metformin-repaglinide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide may inhibit OATP1B1 and modestly increase simvastatin acid exposure, theoretically raising myopathy risk. Clinical evidence of a meaningful effect is limited.
How serious is the interaction between Metformin-repaglinide and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; advise the patient to report muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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