Drug interactions
Metformin-repaglinide + Tafenoquine
Severity: Moderate
Metformin-repaglinide and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits OCT2 and MATE transporters in vitro, which may reduce the renal elimination of metformin and raise its plasma levels. This increases the risk of metformin-related adverse effects including lactic acidosis.
What this interaction means in plain words
Metformin-repaglinide and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE-mediated renal secretion of metformin.
What to do
If coadministration is needed, monitor blood glucose and renal function and consider reducing the metformin dose. Watch for lactic acidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Tafenoquine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits OCT2 and MATE transporters in vitro, which may reduce the renal elimination of metformin and raise its plasma levels. This increases the risk of metformin-related adverse effects including lactic acidosis.
How serious is the interaction between Metformin-repaglinide and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, monitor blood glucose and renal function and consider reducing the metformin dose. Watch for lactic acidosis symptoms.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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