Drug interactions
Metformin-repaglinide + Trilaciclib
Severity: Major
Metformin-repaglinide and Trilaciclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2, MATE1 and MATE-2K, so metformin renal clearance is reduced and its concentrations increase. This raises the risk of metformin toxicity such as lactic acidosis.
What this interaction means in plain words
Metformin-repaglinide and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metformin-repaglinide belongs to Endocrine; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits renal OCT2 and MATE transporters, decreasing metformin elimination.
What to do
Avoid metformin on the day of trilaciclib infusion and consider holding it around dosing as per labeling. Monitor renal function and blood glucose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metformin-repaglinide
Other interactions of Trilaciclib
Frequently asked questions
Can I take Metformin-repaglinide with Trilaciclib?
MediHelp rates the interaction as major. Metformin-repaglinide and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE-2K, so metformin renal clearance is reduced and its concentrations increase. This raises the risk of metformin toxicity such as lactic acidosis.
How serious is the interaction between Metformin-repaglinide and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metformin on the day of trilaciclib infusion and consider holding it around dosing as per labeling. Monitor renal function and blood glucose.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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