Drug interactions
Metformin-repaglinide + Verapamil
Severity: Moderate
Metformin-repaglinide and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may inhibit hepatic OCT1 uptake of metformin, potentially reducing its glucose-lowering effect. Verapamil also inhibits CYP3A4 and may increase repaglinide exposure, raising hypoglycemia risk.
What this interaction means in plain words
Metformin-repaglinide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
OCT1 inhibition reduces hepatic metformin uptake, and CYP3A4 inhibition reduces repaglinide metabolism.
What to do
Monitor blood glucose when verapamil is started or stopped; adjust metformin and repaglinide doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Metformin-repaglinide with Verapamil?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may inhibit hepatic OCT1 uptake of metformin, potentially reducing its glucose-lowering effect. Verapamil also inhibits CYP3A4 and may increase repaglinide exposure, raising hypoglycemia risk.
How serious is the interaction between Metformin-repaglinide and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when verapamil is started or stopped; adjust metformin and repaglinide doses as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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