Drug interactions
Metformin-repaglinide + Voclosporin
Severity: Minor
Metformin-repaglinide and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin may inhibit hepatic uptake transport of OATP1B1 substrates such as repaglinide, which could raise repaglinide plasma levels. Higher exposure increases the risk of hypoglycemia. The magnitude of the effect is not well defined.
What this interaction means in plain words
Metformin-repaglinide and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of repaglinide by voclosporin.
What to do
Monitor blood glucose and watch for hypoglycemia when voclosporin is started. Lower the repaglinide dose if glucose-lowering effect is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Voclosporin?
MediHelp rates the interaction as minor. Metformin-repaglinide and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin may inhibit hepatic uptake transport of OATP1B1 substrates such as repaglinide, which could raise repaglinide plasma levels. Higher exposure increases the risk of hypoglycemia. The magnitude of the effect is not well defined.
How serious is the interaction between Metformin-repaglinide and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and watch for hypoglycemia when voclosporin is started. Lower the repaglinide dose if glucose-lowering effect is excessive.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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