Drug interactions
Metformin-repaglinide + Vonoprazan
Severity: Minor
Metformin-repaglinide and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and could slightly raise repaglinide levels. The clinical effect is likely small, but hypoglycemia is possible.
What this interaction means in plain words
Metformin-repaglinide and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A4 reduces repaglinide metabolism.
What to do
No dose change is generally required; counsel patients on hypoglycemia symptoms and check glucose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Metformin-repaglinide with Vonoprazan?
MediHelp rates the interaction as minor. Metformin-repaglinide and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is a weak CYP3A inhibitor and could slightly raise repaglinide levels. The clinical effect is likely small, but hypoglycemia is possible.
How serious is the interaction between Metformin-repaglinide and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; counsel patients on hypoglycemia symptoms and check glucose if symptoms occur.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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