Drug interactions
Metformin-repaglinide + Zafirlukast
Severity: Moderate
Metformin-repaglinide and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may raise repaglinide exposure, increasing the chance of hypoglycemia. The effect is expected to be modest.
What this interaction means in plain words
Metformin-repaglinide and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast inhibits CYP3A4 and CYP2C9, which contribute to repaglinide metabolism, though evidence is mostly predicted from in vitro data.
What to do
Monitor blood glucose when starting or stopping zafirlukast and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Zafirlukast?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zafirlukast may raise repaglinide exposure, increasing the chance of hypoglycemia. The effect is expected to be modest.
How serious is the interaction between Metformin-repaglinide and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping zafirlukast and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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