Drug interactions
Metformin-repaglinide + Ziprasidone
Severity: Moderate
Metformin-repaglinide and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone can occasionally cause hyperglycemia and may weaken glycemic control in patients taking antidiabetic drugs. Ziprasidone has a lower metabolic liability than many other atypical antipsychotics.
What this interaction means in plain words
Metformin-repaglinide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and impaired glucose regulation oppose the glucose-lowering effects of the antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c after starting ziprasidone and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Ziprasidone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone can occasionally cause hyperglycemia and may weaken glycemic control in patients taking antidiabetic drugs. Ziprasidone has a lower metabolic liability than many other atypical antipsychotics.
How serious is the interaction between Metformin-repaglinide and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting ziprasidone and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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