Drug interactions
Metformin-sitagliptin + Perphenazine
Severity: Minor
Metformin-sitagliptin and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics like perphenazine can raise blood glucose and impair glucose tolerance, though less than some atypicals. This may reduce the effect of metformin and sitagliptin.
What this interaction means in plain words
Metformin-sitagliptin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and reduced insulin secretion oppose antidiabetic therapy.
What to do
Monitor blood glucose when starting or stopping perphenazine and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Metformin-sitagliptin with Perphenazine?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics like perphenazine can raise blood glucose and impair glucose tolerance, though less than some atypicals. This may reduce the effect of metformin and sitagliptin.
How serious is the interaction between Metformin-sitagliptin and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping perphenazine and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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