Drug interactions
Metformin-sitagliptin + Sirolimus
Severity: Moderate
Metformin-sitagliptin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is associated with hyperglycemia, insulin resistance and new-onset diabetes, which can reduce glycemic control on metformin-sitagliptin. Hyperlipidemia and renal effects may add to metabolic burden.
What this interaction means in plain words
Metformin-sitagliptin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition impairs insulin signaling and beta-cell function, opposing antidiabetic effects.
What to do
Monitor blood glucose and HbA1c regularly and intensify antidiabetic therapy as needed. Check renal function because metformin depends on it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Sirolimus?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus is associated with hyperglycemia, insulin resistance and new-onset diabetes, which can reduce glycemic control on metformin-sitagliptin. Hyperlipidemia and renal effects may add to metabolic burden.
How serious is the interaction between Metformin-sitagliptin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly and intensify antidiabetic therapy as needed. Check renal function because metformin depends on it.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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