Drug interactions
Metformin-sitagliptin + Tacrolimus
Severity: Moderate
Metformin-sitagliptin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus commonly causes hyperglycemia and post-transplant diabetes, which may blunt the effect of metformin-sitagliptin. It is also nephrotoxic, raising concern for metformin accumulation.
What this interaction means in plain words
Metformin-sitagliptin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus impairs pancreatic beta-cell insulin secretion and may reduce renal function, opposing antidiabetic effect.
What to do
Monitor glucose and renal function closely, and adjust or stop metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Tacrolimus?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus commonly causes hyperglycemia and post-transplant diabetes, which may blunt the effect of metformin-sitagliptin. It is also nephrotoxic, raising concern for metformin accumulation.
How serious is the interaction between Metformin-sitagliptin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function closely, and adjust or stop metformin if renal function declines.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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