Drug interactions
Methadone + Tamsulosin
Severity: Minor
Methadone and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone is a weak CYP2D6 inhibitor and may slightly raise tamsulosin levels. Both can contribute to orthostatic hypotension, so additive effects on blood pressure and dizziness are possible.
What this interaction means in plain words
Methadone and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methadone belongs to Musculoskeletal; Tamsulosin belongs to Genitourinary.
Why it happens
Methadone weakly inhibits CYP2D6, and both drugs can lower blood pressure.
What to do
Monitor for orthostatic symptoms when starting or increasing either drug. Counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Tamsulosin?
MediHelp rates the interaction as minor. Methadone and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methadone is a weak CYP2D6 inhibitor and may slightly raise tamsulosin levels. Both can contribute to orthostatic hypotension, so additive effects on blood pressure and dizziness are possible.
How serious is the interaction between Methadone and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic symptoms when starting or increasing either drug. Counsel patients to rise slowly.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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